Fluzone Quadrivalent, Fluzone Intradermal Quadrivalent, and Fluzone High-Dose vaccines are given to help prevent influenza disease caused by influenza A and B strains contained in each vaccine. Fluzone Intradermal Quadrivalent vaccine is given to people 18 through 64 years of age. How Is an Intradermal Flu Shot Different? Typical flu shots are intramuscular, which means they go through the skin, a layer of fat, and then the muscle. Intradermal vaccines are injected into the skin through a small, ultra-thin needle.3,4 And since the skin has more specialized immune cells than the muscle, the intradermal vaccine can provide a similar level of protection as the traditional flu shot.