Clinical trials involving DNA and purified inactivated virus vaccines showed they were safe and well-tolerated in small studies and induced neutralizing antibodies. However, these vaccine studies varied by type of vaccine and dosing regimen.
There are several Zika vaccine candidates in various stages of a clinical study.
However, the U.S. FDA has not Approved or Authorized any Zika vaccine as of January 2022.
Zika Vaccine Candidates
TAK-426 (PIZV) is a purified, inactivated, alum-adjuvanted, whole Zika virus vaccine candidate. The vaccine being tested in a phase 1 study is called PIZV or TAK-426 adjuvanted with aluminum hydroxide. The Zika virus vaccine is being tested to provide safety and immunogenicity data to enable the vaccine to be further developed clinically.
Ad26.ZIKV.001 is a replication-incompetent human adenovirus serotype 26 (ad26) vector vaccine candidate. In phase 1 clinical trial, researchers found that two doses of Ad26.ZIKV.001 was safe, causing mild to moderate reactogenicity and induced persistent neutralizing antibody responses. The single-dose had lower peak antibodies but was durable after one year.
mRNA-1893 contains an mRNA sequence encoding for the structural proteins of the Zika virus.
ZPIV is a Zika virus vaccine candidate that consists of a purified formalin-inactivated Zika virus.
INO-A002 is a DNA-encoded monoclonal antibody (dMAb™) technology.
VLA1601 is a purified, inactivated, whole Zika virus vaccine candidate adsorbed on aluminum hydroxide.
VRC5283 is a Zika Virus DNA Vaccine composed of a single closed-circular DNA plasmid that encodes with wild-type precursor transmembrane M and envelope proteins from the H/PF/2013 strain of ZIKV.
Zika Vaccine News
December 9, 2021 - The U.S. CDC issued a Level 2 Travel Advisory for Uttar Pradesh, India.
November 7, 2021 - Researchers at the Institute of Medical Sciences in Banaras Hindu University have reported an important finding on Zika virus pathogenesis, which they claim, will be helpful in understanding the molecular pathogenesis of the virus and in therapeutic development.
June 4, 2021 - Both the mouse and NHP challenge models were further standardized and refined by the ZIKAVAX consortium. "Based on the results, one of the vaccine candidates was selected for evaluation in NHP challenge studies for immunogenicity and efficacy, in comparison to a control vaccine and a first-generation MV-ZIKV vaccine," explains Frédéric Tangy, director of Research at the French National Centre for Scientific Research and head of the Viral Genomics and Vaccination Unit at Paris' Institut Pasteur. "Following the promising results in the preclinical animal models, the selected vaccine candidate was transitioned to further clinical development," adds Roger Le Grand, director of the IDMIT research department.
May 18, 2021 - The Lancet published a study that concluded: TAK-426 was well tolerated, with an acceptable safety profile, and was immunogenic in both flavivirus-naive and flavivirus-primed adults. Based on the safety and immunogenicity profiles of all TAK-426 doses assessed, the 10 μg TAK-426 amount was selected for further clinical development.
May 18, 2021 - The Lancet published a commentary on Zika vaccines: can we solve one problem without creating another? As viable Zika and dengue vaccines are made, it becomes crucial to understand how Zika and dengue immune interactions will affect subsequent flavivirus outbreaks and the use of Zika and dengue vaccines.
March 22, 2021 - Research study: Single-dose of a replication-defective vaccinia virus expressing Zika virus-like particles is protective in mice.
February 18, 2021 - The Center for Infectious Disease Research and Policy at the University of Minnesota, the University of Texas Medical Branch, an expert team of task force members from around the world, and the World Health Organization have developed a draft Zika virus (ZIKV) Research and Development Roadmap. The roadmap is a vital component of the WHO's R&D Blueprint, a global strategy and preparedness plan that allows the activation of R&D activities in advance and during epidemics.
February 16, 2021 - The Zika virus candidate, Ad26.ZIKV.001, a replication-incompetent human adenovirus serotype 26 (ad26) vector, showed promising safety and immunogenicity in phase I clinical trial. Researchers say the vaccine warrants further development should the need reemerge.
October 29, 2020 - Genetic factors that reduce the placenta's capacity to protect a fetus from the Zika virus are described by Brazilian researchers in an article published in PLOS Neglected Tropical Diseases.
October 14, 2020 - Study published by The Lancet: Vertical transmission of Zika virus and its outcomes: a Bayesian synthesis of prospective studies.
August 7, 2020 - A new study describes the preclinical selection and development of a potent ZIKV vaccine from 9 constructs using SAM technology expressing various forms of the ZIKV prM-E antigen. This study identified one ZIKV SAM vaccine candidate, VRC5283, that provided complete protection from the ZIKV challenge in mice and NHPs.
April 15, 2020 - Moderna's Zika vaccine mRNA1893 low dose levels were found very effective.
January 23, 2020 - Researchers at the CUNY Graduate School of Public Health and Health Policy and the National School of Tropical Medicine at Baylor College of Medicine announced that they had developed a computer model representing the impact to a woman if she becomes infected with Zika, how it varies with pregnancy. The potential benefits of a vaccine to prevent Zika infection.
December 19, 2019 - A U.S. NIH-developed Zika vaccine improves fetal outcomes in an animal model.
December 13, 2019 - Researchers have made significant advances in developing a novel vaccine against the Zika virus, potentially leading to the global elimination of the disease.
December 11, 2019 - Study: NS1 DNA vaccination protects against Zika infection through T cell-mediated immunity in immunocompetent mice.
September 3, 2019 - Article: A Gorilla Adenovirus-Based Vaccine against Zika Virus Induces Durable Immunity and Confers Protection in Pregnancy.
January 17, 2019 - A Measles Virus-Based Vaccine Candidate Mediates Protection against Zika Virus in an Allogeneic Mouse Pregnancy Model.
November 2, 2018 - Zika Virus Vaccine Development: Progress in the Face of New Challenges.
November 28, 2017 - Takeda Pharmaceutical announced that its purified, inactivated, alum-adjuvanted whole Zika virus vaccine candidate (TAK-426) has progressed into a Phase 1 clinical trial.
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Note: Zika vaccine content sources include, but are not limited to, the World Health Organization, the US Centers for Disease Control and Prevention, clinicaltrials.gov, and the Precision Vaccinations news network. And this content has been reviewed by healthcare providers.