Updated
September 25th, 2019

Zika Vaccine Research Receives $2 Million From the DOD

Zika Virus Vaccine (ZPIV) candidate has shown protection in small human clinical trials

women soldiers

The US Department of Defense (DOD) is attempting to accelerate clinical research for an effective Zika virus vaccine, which is particularly important for pregnant women. 

As part of a program called the Congressionally Directed Medical Research Program, the DOD is awarding Texas Biomedical Research Institute $2 million over the next 3 years to study a promising experimental Zika vaccine. 

This is important news since a recent study reported women infected with the Zika virus early in pregnancy are almost 17 times more likely to have a child with microcephaly. 

The DOD supports research on many different tropical diseases and is particularly interested in Zika, as pregnant service members may get sent to areas of the world where the Zika virus is endemic, such as Central America. 

Human safety testing has been underway on a formalin-inactivated Zika Virus Vaccine (ZPIV) candidate developed at Walter Reed Army Institute of Research.

Three phase 1, placebo-controlled, double-blind clinical trials of the ZPIV vaccine candidate with aluminum hydroxide adjuvant reported positive results. 

These trials are NCT02963909, NCT02952833, and NCT02937233. 

"If there's something we can do to intervene for a pregnant woman and her fetus who are at risk, it's certainly something we want to be looking at. I think most of the work being done now is focused on how we intervene during pregnancy since that is where the risk is," explained Professor Jean Patterson, Ph.D., a principal investigator on the study. 

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She describes a "sense of urgency" in the medical community to come up with a way to protect this vulnerable population. 

The new Texas Biomedical study’s animal testing has 2 goals:

  • Scientists will look at the possibility that pregnant animals could be vaccinated before being exposed to Zika and be protected from ever getting the virus.
  • Using the transfer of antibodies from humans who have received the experimental vaccine, scientists will see if this method could protect already pregnant animals from passing the virus to the fetus in the womb.

Marmosets housed at the Southwest National Primate Research Center on the Texas Biomed campus northwest of San Antonio, Texas, will serve as animal models for the study.

Marmosets are small nonhuman primates who work well for vaccine research since they breed year round and often have twins or triplets.

The Zika vaccine research project dovetails with Texas Biomed's mission to eradicate the threat of infectious diseases and protect global human health. This work is supported by Department of Defense grant # W81XWH1920020.

Texas Biomed is one of the world's leading independent biomedical research institutions dedicated to advancing health worldwide through innovative biomedical research.

Other researchers around the world are trying to develop Zika vaccines using different platforms like DNA vaccines, live attenuated vaccines, and adeno-associated virus vaccines.